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  • Title: Determination and in-process control of zolpidem synthesis by high-performance liquid chromatography.
    Author: Laviana L, Mangas C, Fernández-Marí F, Bayod M, Blanco D.
    Journal: J Pharm Biomed Anal; 2004 Nov 19; 36(4):925-8. PubMed ID: 15533692.
    Abstract:
    A high-performance liquid chromatographic assay with diode-array detection has been developed for the in-process control of zolpidem synthesis and for the analysis of the drug and its synthetic intermediates. The separation uses a 4.6mm i.d. reversed-phase Kromasil C(18) (150 mm) column, 5 microm particle size with a gradient elution mode of acetonitrile and 0.02 M NH(4)OAc (adjusted to pH 8.0) as the mobile phase (flow rate 1.0 mlmin(-1)). The analysis is performed in 12 min. The method is simple, rapid and highly specific.
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