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  • Title: Neurovirulence of mumps virus: intraspinal inoculation test in marmosets.
    Author: Saika S, Kidokoro M, Aoki A, Ohkawa T.
    Journal: Biologicals; 2004 Sep; 32(3):147-52. PubMed ID: 15536045.
    Abstract:
    An intraspinal inoculation test of mumps virus using marmosets was performed in order to develop a neurovirulence test of mumps vaccines. In the group inoculated with non-neurovirulent Jeryl Lynn vaccine strain at 10(2.0) pfu/dose, there were only minimal histopathological changes in 3 of the 5 marmosets. In contrast, all marmosets inoculated with neurovirulent Urabe and NK-M46 vaccine strains developed extensive encephalitis and meningitis. Thus, this marmoset model, which can distinguish between non-neurovirulent and neurovirulent vaccine strains, is useful for evaluating neurovirulence of vaccine strains and elucidating the molecular pathogenesis of mumps.
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