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  • Title: Electroconvulsive therapy for the treatment of clozapine nonresponders suffering from schizophrenia--an open label study.
    Author: Kho KH, Blansjaar BA, de Vries S, Babuskova D, Zwinderman AH, Linszen DH.
    Journal: Eur Arch Psychiatry Clin Neurosci; 2004 Dec; 254(6):372-9. PubMed ID: 15538604.
    Abstract:
    OBJECTIVE: This open label study describes the efficacy of electroconvulsive therapy (ECT) as adjunctive treatment in clozapine nonresponders suffering from schizophrenia. METHOD: The results of clozapine and ECT treatment in 11 clozapine nonresponders suffering from schizophrenia are reported in terms of remission and relapse. RESULTS: Eight patients had a remission with this combination treatment. After remission of symptoms five patients had a relapse. Three of the five patients who relapsed had a second successful ECT course and remained well with maintenance ECT and clozapine. No evidence for adverse effects was found. CONCLUSION: Adjunctive ECT can be efficacious in clozapine nonresponders suffering from schizophrenia.
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