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  • Title: Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats.
    Author: Shinomiya K, Omichi J, Ohnishi R, Ito H, Yoshida T, Kamei C.
    Journal: Eur J Pharmacol; 2004 Nov 19; 504(3):185-9. PubMed ID: 15541420.
    Abstract:
    The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid at a dose of 500 and 200 mg/kg, respectively. On the other hand, no remarkable effects were observed with dihydrocaffeic acid even at a dose of 500 mg/kg. Caffeine caused a significant increase in sleep latency and waking time and decrease in non-rapid eye movement sleep time at a dose of 10 mg/kg. In contrast, chlorogenic acid and its metabolites had no significant effects on each sleep state. From these results, it may be concluded that chrologenic acid caused a mild arousal effect compared with that of caffeine, and the effect of chlorogenic acid may have occurred through its metabolite caffeic acid.
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