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  • Title: Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum.
    Author: Simsek-Duran F, Linden DJ, Lonart G.
    Journal: Nat Neurosci; 2004 Dec; 7(12):1296-8. PubMed ID: 15543142.
    Abstract:
    Long-term potentiation (LTP) of granule cell-Purkinje cell synapses in the mouse cerebellum requires phosphorylation by protein kinase A of the active-zone protein RIM1alpha at Ser413. Here, we show that the adapter protein 14-3-3 readily binds phosphorylated Ser413 in RIM1alpha, and that presynaptic transfection with a dominant-negative 14-3-3eta mutant, or a RIM1alpha mutant with enhanced 14-3-3 binding, inhibits LTP. Thus, RIM1alpha phosphorylation triggers presynaptic LTP in part through recruitment of 14-3-3 to phospho-Ser413-RIM1alpha.
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