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  • Title: Upper airway function in Ondine's curse.
    Author: Olson TS, Woodson GE, Heldt GP.
    Journal: Arch Otolaryngol Head Neck Surg; 1992 Mar; 118(3):310-2. PubMed ID: 1554454.
    Abstract:
    Congenital central alveolar hypoventilation (Ondine's curse) is a rare disorder with absence of automatic control of ventilation but preservation of voluntary breathing. Phrenic pacing, used to treat this condition, is usually not successful without a tracheotomy. We performed fiberoptic videoendoscopy on an affected infant airway. During wakefulness and ventilation by a negative pressure ventilator, the airway was normal, but with sleep onset, passive inspiration produced phasic epiglottic collapse. This case demonstrates the importance of central control in maintaining upper airway patency.
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