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  • Title: Intervention of hepatic glucose production. Small molecule regulators of potential targets for Type 2 diabetes therapy.
    Author: Barf T.
    Journal: Mini Rev Med Chem; 2004 Oct; 4(8):897-908. PubMed ID: 15544551.
    Abstract:
    Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11 beta-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.
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