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  • Title: Evolutionary breakpoint analysis on Y chromosomes of higher primates provides insight into human Y evolution.
    Author: Wimmer R, Kirsch S, Rappold GA, Schempp W.
    Journal: Cytogenet Genome Res; 2005; 108(1-3):204-10. PubMed ID: 15545731.
    Abstract:
    Comparative FISH mapping of PAC clones covering almost 3 Mb of the human AZFa region in Yq11.21 to metaphases of human and great apes unravels breakpoints that were involved in species-specific Y chromosome evolution. An astonishing clustering of evolutionary breakpoints was detected in the very proximal region on the long arm of the human Y chromosome in Yq11.21. These breakpoints were involved in deletions, one specific for the human and another for the orang-utan Y chromosome, in a duplicative translocation/transposition specific for bonobo and chimpanzee Y chromosomes and in a pericentric inversion specific for the gorilla Y chromosome. In addition, our comparative results allow the deduction of a model for the human Y chromosome evolution.
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