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  • Title: Pediatric hepatic angiosarcoma: case report and review of the literature.
    Author: Dimashkieh HH, Mo JQ, Wyatt-Ashmead J, Collins MH.
    Journal: Pediatr Dev Pathol; 2004; 7(5):527-32. PubMed ID: 15547777.
    Abstract:
    Pediatric hepatic angiosarcoma (PHAS) is a rare tumor, which usually presents as a rapid enlargement of the liver. To date, surgery, chemotherapy, and radiotherapy have not improved the poor prognosis of PHAS with only three survivors reported. The histology of PHAS is distinct from adult angiosarcoma, because PHAS displays hypercellular whorls of sarcomatous cells, or "kaposiform" spindle cells, in addition to the general features of angiosarcoma. We report a case of PHAS that was treated with vascular ablation, chemotherapy, and liver transplantation. Lung metastases occurred 14 months posttransplant.
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