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  • Title: Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection.
    Author: Lin Y, Roberts TJ, Spence PM, Brutkiewicz RR.
    Journal: J Leukoc Biol; 2005 Feb; 77(2):151-8. PubMed ID: 15548574.
    Abstract:
    Mice were infected with lymphocytic choriomeningitis virus (LCMV) to determine if changes in CD1d expression occurred during an acute virus infection. It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (MPhi) was observed for at least 3 months post-LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell-surface expression on DC and MPhi was independent of interferon-gamma and interleukin-12 expression but partially recovered in transporter associated with antigen processing-1-deficient mice, suggesting that CD8+ T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.
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