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  • Title: New method to prepare peptide-oligonucleotide conjugates through glyoxylic oxime formation.
    Author: Singh Y, Defrancq E, Dumy P.
    Journal: J Org Chem; 2004 Nov 26; 69(24):8544-6. PubMed ID: 15549841.
    Abstract:
    A new method to prepare peptide-oligonucleotide conjugates through chemoselective glyoxylic oxime linkage is reported. A novel phosphoramidite reagent, readily accessible from serine, was prepared and used in automated DNA synthesis to prepare oligonucleotides carrying a glyoxylic aldehyde functionality at the 5' terminus. This was efficiently coupled to a peptide functionalized with an aminooxy group. The method could be of general use to prepare a broad range of oligonucleotide conjugates.
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