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  • Title: Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia.
    Author: Wang S, Degar BA, Zieske A, Shafi NQ, Rose MG.
    Journal: Am J Hematol; 2004 Dec; 77(4):391-6. PubMed ID: 15551287.
    Abstract:
    We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.
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