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  • Title: [Evaluation of prophylactic hepatic arterial infusion chemotherapy after curative hepatectomy for metastatic colorectal cancer].
    Author: Tokuoka M, Kashiwazaki M, Takeda Y, Hasuike Y, Mishima H, Ikenaga M, Masuda N, Hirao M, Fujitani K, Sawamura T, Tsujinaka T.
    Journal: Gan To Kagaku Ryoho; 2004 Oct; 31(11):1806-8. PubMed ID: 15553722.
    Abstract:
    We evaluated the effect of hepatic arterial infusion (HAI) chemotherapy after curative resection of liver metastases of colorectal cancer. A total of 161 patients underwent curative resection of liver metastases. Among them, 50 patients underwent HAI of 5-FU, and 111 patients had no HAI therapy. The 50% disease-free survival time (50% DFS) was 758 days and 342 days in the HAI group and the non-HAI group (logrank test, p<0.01), and the 50% overall survival time (50% OS) was 978 days versus 730 days (p<0.05), respectively. Among the 71 patients with multiple resectable metastases (H2 or H3), the HAI group had a significantly superior 50% DFS. HAI therapy seems to be an effective form of adjuvant chemotherapy after hepatic resection of metastatic colorectal cancer.
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