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  • Title: The Bacillus subtilis DnaD protein: a putative link between DNA remodeling and initiation of DNA replication.
    Author: Turner IJ, Scott DJ, Allen S, Roberts CJ, Soultanas P.
    Journal: FEBS Lett; 2004 Nov 19; 577(3):460-4. PubMed ID: 15556628.
    Abstract:
    The Bacillus subtilis DnaD protein is an essential protein and a component of the oriC and PriA primosomal cascades, which are responsible for loading the main replicative ring helicase DnaC onto DNA. We present evidence that DnaD also has a global DNA architectural activity, assembling into large nucleoprotein complexes on a plasmid and counteracting plasmid compaction in a manner analogous to that recently seen for the histone-like Escherichia coli HU proteins. This DNA-remodeling role may be an essential function for initiation of DNA replication in the Gram +ve B. subtilis, thus highlighting DnaD as the link between bacterial nucleoid reorganization and initiation of DNA replication.
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