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  • Title: The role of bestrophin in airway epithelial ion transport.
    Author: Duta V, Szkotak AJ, Nahirney D, Duszyk M.
    Journal: FEBS Lett; 2004 Nov 19; 577(3):551-4. PubMed ID: 15556645.
    Abstract:
    The purpose of this study was to identify Cl- channels in the basolateral membrane of airway epithelial cells at the molecular level. We have focused on a new family of Cl- channels, bestrophins, which have previously been identified in retinal pigment epithelium. RT-PCR, Western blot and confocal microscopy studies revealed the presence of bestrophin in airway epithelial cells. Decreasing bestrophin expression using siRNA resulted in diminished 36Cl- flux. These studies also showed that bestrophin regulation is similar to that of native basolateral Cl- channels. The data indicate that the presence of a functional bestrophin may contribute to the basolateral cell conductance in airway epithelial cells.
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