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  • Title: Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines.
    Author: Sadashiva MP, Mallesha H, Hitesh NA, Rangappa KS.
    Journal: Bioorg Med Chem; 2004 Dec 15; 12(24):6389-95. PubMed ID: 15556757.
    Abstract:
    Cycloaddition of C-imidazolyl-N-phenylnitrones with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against F. moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared.
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