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  • Title: [The absorption kinetics of silymarin microemulsion in rat intestine].
    Author: Yuan Q, Li XR, Wang HJ, Li XY, Liu Y.
    Journal: Yao Xue Xue Bao; 2004 Aug; 39(8):631-4. PubMed ID: 15563067.
    Abstract:
    AIM: To survey the morphology and size distribution of silymarin microemulsion, to investigate the absorption of silymarin microemulsion in rat intestine compared with the absorption of silymarin micelle in rat Jejunum. METHODS: The intestine in rats was canulated for in situ recirculation. RESULTS: The absorption rate constants (Ka) of silymarin microemulsion at the entire intestine, ileum jejunum, duodenum and colon were 6.22 x 10(-2), 2.27 x 10(-2), 1.9 x 10(-2), 1.9 x 10(-2), 1.05 x 10(-2) and 0.43 x 10(-2) h(-1), respectively. The absorption rate constants of two kinds of silymarin micelle at jejunum were 0.36 x 10(-2), 0.65 x 10(-2) h(-1). CONCLUSION: Silymarin microemulsion was well absorbed at the middle and lower segments of intestine in rats. The absorption was a first-order process with the passive diffusion mechanism.
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