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  • Title: Total synthesis of (-)-disorazole C1.
    Author: Wipf P, Graham TH.
    Journal: J Am Chem Soc; 2004 Dec 01; 126(47):15346-7. PubMed ID: 15563138.
    Abstract:
    The antimitotic natural product disorazole C1 was isolated in 1994 from the fermentation broth of the myxobacterium Sorangium cellulosum. We have developed a highly convergent and stereoselective total synthesis of this compound which establishes its relative and absolute configuration. Key features of our synthesis include a highly convergent strategy and selective functional group manipulations that minimize decomposition of the sensitive polyene macrodiolide.
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