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  • Title: Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa.
    Author: Ando T, Kodama N, Ishikawa T, Naruo T, Tachikawa N, Nozaki T, Okabe K, Takeuchi K, Masuda A, Kawamura N, Komaki G.
    Journal: Psychiatr Genet; 2004 Dec; 14(4):215-8. PubMed ID: 15564896.
    Abstract:
    Energy expenditure abnormalities have been observed in anorexia nervosa (AN). The uncoupling proteins (UCPs) have been implicated as having a role in energy metabolism and thermogenesis, and an association between a marker flanking the UCP-2/UCP-3 gene cluster and AN has been reported. Also known are insertion/deletion and -866G/A polymorphisms in the UCP-2 gene, and the -55C/T polymorphism in the UCP-3 gene. Differences in these alleles are reportedly related to changes in energy expenditure, body mass index, fat tissue accumulation and obesity. Therefore, this case-control association analysis was done to determine whether any of these UCP-2/3 gene polymorphisms are related to a predisposition to AN. In analysis of a cohort of 106 female Japanese AN sufferers and 126 normal female controls, we found no between-group differences in the polymorphism frequencies of these groups. The hypothesis that differences in the UCP-2/3 gene influence the susceptibility to AN was not supported.
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