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  • Title: The blastogenic response of rabbit lymphocytes stimulated with autologous cells.
    Author: Milthorp P, Richter M.
    Journal: Immunology; 1979 Mar; 36(3):375-80. PubMed ID: 155652.
    Abstract:
    Rabbit WBC and spleen cells respond with marked blastogenesis and mitosis when cultured with mitomycin-C treated autologous sacculus rotundus, appendix and Peyer's patches cells in the one-way rabbit mixed leucocyte reaction (MLR). A lesser response is observed using stimulating cells of the other lymphoid organs. The blastogenic response in the one-way 'autologous MLR' cannot be attributed to mitogenic factors released from the mitomycin-C treated stimulator cells since it is also observed in the 'two-way autologous MLR', using untreated stimulator cells. Several explanations are proposed to account for the 'autologous MLR'.
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