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  • Title: Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.
    Author: Rosa DD, Pasqualotto AC, de Quadros M, Prezzi SH.
    Journal: Braz J Infect Dis; 2004 Aug; 8(4):328-30. PubMed ID: 15565265.
    Abstract:
    The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
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