These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Significance of membrane type-1 matrix metalloproteinase expression in breast cancer].
    Author: Yao GY, Yang MT, Rong TH, He P.
    Journal: Ai Zheng; 2004 Nov; 23(11 Suppl):1482-6. PubMed ID: 15566663.
    Abstract:
    BACKGROUND & OBJECTIVE: Recent researches manifested that MT1- MMP (Membrane type-1 matrix metalloproteinase) is essential for breast cancer invasion and metastasis, but there are few reports about the clinical value of MT1- MMP. This study was designed to investigate the clinical significance of MT1-MMP protein and mRNA expression in human breast cancers. METHODS: Forty-six human breast cancer tissues were collected. MT1-MMP protein and mRNA expression were detected by semi-quantitative reverse transcriptase chain reaction (RT-PCR) and immunohistochemistry assay and their correlations with clinicopathological factors were analyzed. RESULTS: The expression of MT1-MMP protein was positive in 52.2% of forty-six breast cancer tissues. The positive rates were 12.5%, 54.8% and 85.7% in stageI, stage II and stage III human breast cancers, respectively (P < 0.05), and 11.1%, 59.4% and 80.0% in the group of T(1), T(2) and T(3) (P < 0.05), and 27.3%, 66.7% and 100.0% in the group of N(0), N(1) and N(2) (P < 0.05). MT1-MMP mRNA expression were detected in all of the carcinomas. The means of MT1-MMP mRNA expression relative quantities were 0.4730, 0.6950 and 0.9100 in stageI, stage II and stage III human breast cancers, respectively (P < 0.05), and 0.5240, 0.7150 and 0.8220 in the group of T(1),T(2) and T(3) (P < 0.05), and 0.6305, 0.7022 and 0.8700 in the group of N(0), N(1) and N(2)(P < 0.05). There were no relations between the MT1-MMP protein or mRNA expression and ER, PR or C-erbB-2(P >0.05). CONCLUSION: MT1-MMP protein and mRNA expression in human breast cancers had positive correlation with the stage,the tumor size and lymph node metastasis. MT1-MMP can be a predictor for the ability of breast cancer invasion and metastasis.
    [Abstract] [Full Text] [Related] [New Search]