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  • Title: Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women.
    Author: da Costa LS, de Oliveira MA, Rubim VS, Wajngarten M, Aldrighi JM, Rosano GM, Neto CD, Gebara OC.
    Journal: Am J Cardiol; 2004 Dec 01; 94(11):1453-6. PubMed ID: 15566926.
    Abstract:
    The administration of oral raloxifene in 30 postmenopausal hypertensive women was evaluated to demonstrate its effect on arterial stiffness. Casual and ambulatory blood pressure (BP) and pulse-wave velocity (PWV) data were obtained before and after patients received raloxifene, estrogen-progestin replacement therapy, or placebo in a randomized crossover study. It was shown that the 2 therapies decreased BP and carotid-femoral PWV, and the effect of raloxifene on vascular compliance was independent of the effects on BP.
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