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  • Title: Effects of the plant alkaloid thaliblastine on non-cross-resistant and sensitive human leukemia cells in relation with reversal of acquired anthracycline resistance.
    Author: Horvath LE, Konstantinov SM, Ilarionova MV, Todorov DK.
    Journal: Fitoterapia; 2004 Dec; 75(7-8):712-7. PubMed ID: 15567248.
    Abstract:
    Thaliblastine exhibits dose dependent cytotoxic effect on HL-60, HL-60/DOX, RHE and HD-MY-2 leukemia cells. Additionally, typical for apoptosis oligonucleosomal DNA fragmentation could be detected in leukemia cells treated with thaliblastine. Moreover, an MDR-phenotype reversing effect of thaliblastine was also identified.
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