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  • Title: Presumed pharmacologically induced change from upbeat- to downbeat nystagmus in a patient with Wernicke's encephalopathy.
    Author: Kastrup O, Maschke M, Keidel M, Diener HC.
    Journal: Clin Neurol Neurosurg; 2004 Dec; 107(1):70-2. PubMed ID: 15567556.
    Abstract:
    A case of Wernicke's encephalopathy due to proven thiamine deficiency suffering from upbeat nystagmus (UN) changing to downbeat nystagmus (DN) after a latency of 1 year is presented. The case was also notable for the finding of positive oligoclonal bands in the CSF. The underlying pathophysiological mechanisms and a possible effect of baclofen treatment are discussed.
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