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  • Title: [Radiation-induced rat cerebral neuron apoptosis].
    Author: Feng WF, Qi ST, Qiu BH, Yang KJ, Huang LJ.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 Nov; 24(11):1289-91. PubMed ID: 15567782.
    Abstract:
    OBJECTIVE: To explore the correlation between X-ray-induced rat cerebral neuron apoptosis and radiation doses. METHODS: In a controlled experiment, the rats in the experimental group received X-ray radiation at different doses (2, 4, 6 and 8 Gy), and the apoptotic cerebral neurons were counted after in situ end-labeling and immunohistochemical staining. RESULTS: X-ray radiation induced apoptosis of rat cerebral neurons, and the apoptotic rate varied with the radiation doses. Significant difference in the apoptotic rate was noted before and after radiation (P<0.0001), and between different radiation dose groups (P<0.005). The apoptotic rate differed significantly at different time points after the radiation. CONCLUSION: Low or medium doses of X-ray is able to induce rat cerebral neuron apoptosis depending on the radiation doses and following a definable time course.
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