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  • Title: [Effect of H2-blockers and proton pump inhibitors on intragastric acidity and intraesophageal pH in patients with gastroesophageal reflux disease].
    Author: Ivanov AN, Iakovenko EP, Iakovenko AV.
    Journal: Eksp Klin Gastroenterol; 2004; (4):16-20, 107. PubMed ID: 15568661.
    Abstract:
    We investigated 53 patients with GORD symptoms and a various grade (A-C according to the Los Angeles classification) of reflux oesophagitis diagnosed in the course of upper endoscopy. By using 24-hour gastric and esophageal pH-metry we investigated the antisecretory effect of single-dose morning or evening administration of famotidine, omeprazole and rabeprazole. We revealed essential superiority of single-dose morning omeprazole and rabeprazole administration in daily gastric acid release suppression and gastro-esophageal reflux prevention as compared with morning famotidine and evening omeprazole and rabeprazole administration in GORD patients.
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