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  • Title: [Expression and significance of alpha5beta1 integrin in abnormal scars].
    Author: Yu Y, He GZ, Wu Y, Huang CB.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2004 Jul; 20(4):271-3. PubMed ID: 15568751.
    Abstract:
    OBJECTIVE: To study the expression of alpha5beta1 integrin in the abnormal scars and its role and significance in the formation and development of abnormal scars. METHODS: The expression of alpha5beta1 integrin was observed in hypertrophic scar (15 samples), keloid (15 samples) and normal skin (10 samples) with SP immunohistochemical method and colloidal gold immuno-electron microscopic technique. The data were semi-quantitatively analyzed. RESULTS: The expression levels of alpha5beta1 integrin in the fibroblasts of keloids and hypertrophic scars were higher than normal skin; the expression of alpha5beta1 integrin in the fibroblasts of keloids was higher than hypertrophic scars (P < 0.01). CONCLUSION: The alpha5beta1 integrin appears to have close relation to the formation and development of abnormal scars. To find a way to decrease the expression level of alpha5beta1 integrin in fibroblasts may be a new approach to inhibit scar hypertrophy.
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