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  • Title: New luffariellolide derivatives from the Indonesian sponge Acanthodendrilla sp.
    Author: Elkhayat E, Edrada R, Ebel R, Wray V, van Soest R, Wiryowidagdo S, Mohamed MH, Müller WE, Proksch P.
    Journal: J Nat Prod; 2004 Nov; 67(11):1809-17. PubMed ID: 15568767.
    Abstract:
    Investigation of the Indonesian sponge Acanthodendrilla sp. afforded five new luffariellolide-related sesterterpenes, acantholides A-E (1-5), in addition to luffariellolide and its 25-O-methyl and 25-O-ethyl derivatives. All structures were unambiguously established by 1D and 2D NMR and MS spectroscopy. Acantholide D and E are derivatives comprising the 1-acetylcyclopentan-5-ol moiety, which are new variants of the C(14)-C(20) segment for this type of linear sesterterpenes. Luffariellolide and its 25-O-methyl congener as well as acantholide E (5) were cytotoxic against the mouse lymphoma L5187Y cell line. Acantholide B (2), luffariellolide, and its 25-O-methyl congener were active against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, the Gram-negative bacterium Escherichia coli, the yeast Candida albicans, and the plant pathogenic fungus Cladosporium herbarum.
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