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  • Title: Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus.
    Author: Cheng Y, Schneider B, Riese U, Schubert B, Li Z, Hamburger M.
    Journal: J Nat Prod; 2004 Nov; 67(11):1854-8. PubMed ID: 15568775.
    Abstract:
    Two new yellow pigments, farinosones A (1) and B (2), were isolated from the mycelial extract of the entomogenous fungal strain Paecilomyces farinosus RCEF 0101, together with farinosone C (3), a new metabolite derived from an early step of pyridone alkaloid biosynthesis. The structures were determined by spectroscopic means, in particular by extensive NMR experiments. Compounds 1 and 3 induced neurite outgrowth in the PC-12 cell line at concentrations of 50 microM, while compound 2 was inactive. No cytotoxicity was observed for compounds 1-3 in PC-12 cells when tested at 50 microM concentration in the MTT assay.
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