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  • Title: Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease.
    Author: Tursen U, Eskandari G, Kaya TI, Tamer L, Ikizoglu G, Atik U.
    Journal: Int J Dermatol; 2004 Dec; 43(12):900-3. PubMed ID: 15569012.
    Abstract:
    BACKGROUND: Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD. METHODS: In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects. RESULTS: Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < 0.05); however, there was no difference in serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant. CONCLUSIONS: The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.
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