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  • Title: Review article: orofacial granulomatosis.
    Author: Leão JC, Hodgson T, Scully C, Porter S.
    Journal: Aliment Pharmacol Ther; 2004 Nov 15; 20(10):1019-27. PubMed ID: 15569103.
    Abstract:
    Orofacial granulomatosis is an uncommon clinicopathological entity describing patients who have oral lesions characterized by persistent and/or recurrent labial enlargement, oral ulcers and a variety of other orofacial features, who on lesional biopsy have lymphoedema and non-caseating granulomas. The aetiology of oral lesions with non-caseating granulomas includes oral Crohn's disease (some patients with oral lesions will develop typical bowel symptoms of Crohn's disease in ensuing months to years), tooth-associated infections, sarcoidosis and food or contact allergies. Treatment of orofacial granulomatosis is not reliably effective and may not be always necessary, although most patients do require some medical intervention.
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