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  • Title: Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor.
    Author: Ashrani AA, Reding MT, Shet A, Osip J, Humar A, Lake JR, Key NS.
    Journal: Haemophilia; 2004 Nov; 10(6):735-7. PubMed ID: 15569170.
    Abstract:
    We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.
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