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  • Title: Specific oral contraceptive use and venous thromboembolism resulting in hospital admission.
    Author: Heuser P, Tonga K, Hopkins R, Henderson M, Weatherall M, Metcalfe S, Beasley R.
    Journal: N Z Med J; 2004 Nov 26; 117(1206):U1176. PubMed ID: 15570345.
    Abstract:
    OBJECTIVE: To determine whether there is an increased risk of venous thromboembolism (VTE) with anti-androgen oral contraceptives containing cyproterone acetate and ethinyloestradiol. METHODS: Comparison of the frequency of specific oral contraceptive use in patients aged 15 to 55 years discharged from hospital with radiologically confirmed deep vein thrombosis (DVT) and/or pulmonary embolism (PE) with the expected frequency of use derived from national prescription data. MAIN OUTCOME MEASURE: Ratio of observed frequency of specific oral contraceptive use in patients with VTE versus expected frequency of use. RESULTS: The rank order for observed versus expected use was anti-androgen > third-generation, > second-generation, > progestogen-only oral contraceptive agents with ratios of 1.93, 1.36, 0.70, and 0.39, respectively. CONCLUSION: The risk of VTE resulting in hospital admission associated with anti-androgen oral contraceptive use is at least as high as with third generation use.
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