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  • Title: Muscle energy metabolism in female DMD/BMD carriers: a 31P-MR spectroscopy study.
    Author: Barbiroli B, Funicello R, Ferlini A, Montagna P, Zaniol P.
    Journal: Muscle Nerve; 1992 Mar; 15(3):344-8. PubMed ID: 1557082.
    Abstract:
    31P nuclear magnetic resonance spectroscopy (31P-MRS) was used to investigate the energy metabolism of the gastrocnemius muscle in 16 DMD/BMD female carriers. No significant difference was found with the controls in the resting muscle, while all carriers showed a decreased ability to perform work, and a higher Pi/PCr ratio for comparable relative levels of steady-state work. The rate of postexercise recovery of PCr/Pi ratio was lower in all carriers. The decreased rate of PCr/Pi recovery appears to be mainly due to a decreased rate of Pi recovery. Our findings show abnormal muscle energy metabolism in DMD/BMD female carriers.
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