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  • Title: p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells.
    Author: Verdaguer E, Jordà EG, Canudas AM, Jiménez A, Folch J, Rimbau V, Pallàs M, Camins A.
    Journal: Brain Res; 2004 Dec 31; 1030(2):297-302. PubMed ID: 15571679.
    Abstract:
    Kainic acid (KA) treatment induced neuronal death and apoptosis in murine cerebellar granule cells (CGNs) cultures from both wild-type and knockout p21(-/-) mice. There was not statistically significant difference in the percentage of neuronal apoptosis among strains. KA-induced neurotoxicity was prevented in the presence of NBQX (20 microM) and GYKI 52446 (20 microM), but not by z-VAD-fmk, suggesting that caspases are not involved in the apoptotic process. Data suggest that p21(WAF/Cip) was unable to modulate KA-induced apoptosis in murine CGNs.
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