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  • Title: Chorionic villus metaphase chromosomes and interphase nuclei analysed by chromosomal in situ suppression (CISS) hybridization.
    Author: Klever M, Grond-Ginsbach CJ, Hager HD, Schroeder-Kurth TM.
    Journal: Prenat Diagn; 1992 Jan; 12(1):53-9. PubMed ID: 1557311.
    Abstract:
    Metaphase chromosomes and interphase nuclei of chorionic villus samples (CVS) in five cases were studied after treatment with trypsin and post-fixation in formaldehyde by chromosomal in situ suppression (CISS) hybridization. Our modified protocol enables the use of in situ hybridization techniques on CVS preparations after 42 h of culture. A balanced translocation and trisomy 13 were identified with the aid of CISS hybridization.
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