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  • Title: Synthesis of a Gln-Phe hydroxy-ethylene dipeptide isostere.
    Author: Haug BE, Rich DH.
    Journal: Org Lett; 2004 Dec 09; 6(25):4783-6. PubMed ID: 15575685.
    Abstract:
    [structure: see text] The protected Gln-Phe hydroxyethylene dipeptide isostere 1 was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as 2 with functionalized P1 side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.
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