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  • Title: [Biological activity of FGF-23 and pathophysiologic role in chronic kidney disease].
    Author: Yamashita T.
    Journal: Clin Calcium; 2004 May; 14(5):760-3. PubMed ID: 15577039.
    Abstract:
    Recent studies indicate that FGF-23, which was originally identified as an endogenous causative factor for hypophosphatemic diseases, is a physiologic factor for the regulation of phosphate homeostasis and vitamin D metabolism. In patients with renal failure, serum concentrations of FGF-23 positively correlate with serum levels of phosphate, Ca-P product, and prathyroid hormone. It is plausible that increased FGF-23 levels are responsible for the reduction of 1,25(OH)2D levels in the early stage of renal insufficiency and also involved in the development of secondary hyperparathyroidism in chronic and end-stage kidney disease.
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