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  • Title: Marfan syndrome and mitral valve prolapse.
    Author: Weyman AE, Scherrer-Crosbie M.
    Journal: J Clin Invest; 2004 Dec; 114(11):1543-6. PubMed ID: 15578086.
    Abstract:
    Mitral valve prolapse (MVP), an abnormal displacement into the left atrium of a thickened and redundant mitral valve during systole, is a relatively frequent abnormality in humans and may be associated with serious complications. A recent study implicates fibrillin-1, a component of extracellular matrix microfibrils, in the pathogenesis of a murine model of MVP. This investigation represents an initial step toward understanding the mechanisms involved in human MVP disease and the development of potential treatments.
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