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  • Title: Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease.
    Author: Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC.
    Journal: Acta Neuropathol; 1992; 83(2):134-9. PubMed ID: 1557945.
    Abstract:
    We report the presence of autophagic vacuoles (AV) in neuronal perikarya and neuronal processes of rodents with experimental scrapie and Creutzfeldt-Jakob disease. AV were composed of sequestrated cytoplasmic areas containing ribosomes and occasionally mitochondria and small secondary vacuoles. The formation of AV may contribute to neuronal degeneration and ultimately to neuronal loss.
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