These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Surgical treatment of pulmonary metastases of colorectal cancer. Do the indications evolved?].
    Author: Pop D, Venissac N, Leo F, Karimdjee BS, Lopez S, Mouroux J.
    Journal: Ann Chir; 2004 Dec; 129(10):589-95. PubMed ID: 15581820.
    Abstract:
    AIM OF THE STUDY: The aim of this study was to evaluate a single-institution experience in the surgical treatment of lung metastases from colorectal cancer. PATIENTS AND METHODS: During a 16 years period, 42 patients underwent lung metastasectomy at the University Hospital of Nice for a total of 57 surgical interventions. Data were retrospectively collected and analysed in term of prognostic factors and long-term survival. RESULTS: The mean age was 64.5 years and there were 26 males and 16 females. In 36 cases lung metastasis were metachronous and the disease-free mean interval was 28.7 months. Eighteen patients had bilateral disease. In ten patients hepatic metastasectomy was done before lung resection. Forty-seven operations were performed for the 1(st) episode of lung metastasis (1 bilobectomy, 21 lobectomy, 4 segmentectomy and 38 wedge resections). Mediastinal metastatic disease was present in six patients. No patient died and the postoperative morbidity was 6.25%. Six patients needed operation for recurrent disease. Two patients died after completion pneumonectomy. Overall five and ten-year survival were 29.5 respectively 26.2%. The log-rank test identified two significant prognostic factors: radicality of metastasectomy (P =0.0066) and a disease-free interval longer than two years (P= 0.0021). CONCLUSION: Our study suggests that local control of lung metastasis can improve survival only when a radical resection can be achieved. Selection criteria need to be improved in order to avoid unnecessary lung resection in patients with high risk of recurrences. The Pet-scan should probably have a certain interest in selecting these patients.
    [Abstract] [Full Text] [Related] [New Search]