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  • Title: Vitamin E can protect against ultraviolet radiation-induced cataract in albino rats.
    Author: Ayala MN, Söderberg PG.
    Journal: Ophthalmic Res; 2004; 36(5):264-9. PubMed ID: 15583432.
    Abstract:
    PURPOSE: To investigate if vitamin E protects against ultraviolet B radiation (UVB)-induced cataract. METHODS: Albino Sprague-Dawley rats were divided into two groups: one group was fed vitamin E, while the other group was used as a control. Both groups were exposed to UVB. The rats were sacrificed, lenses extracted, forward light scattering was measured, and vitamin E and glutathione (GSH) contents were determined. RESULTS: Lenses in the vitamin E group developed slight opacities, while lenses in the control group developed nuclear cataracts. Forward light scattering in lenses of the control group was higher than in lenses in the vitamin-E-supplemented group. Vitamin E and GSH concentrations were higher in lenses treated with vitamin E than in the untreated group. CONCLUSIONS: Vitamin E protects the lens against UVB-induced cataract. Vitamin E protects directly as an antioxidant and/or indirectly through increased levels of GSH.
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