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  • Title: The total synthesis of (-)-SNF4435 C and (+)-SNF4435 D.
    Author: Parker KA, Lim YH.
    Journal: J Am Chem Soc; 2004 Dec 15; 126(49):15968-9. PubMed ID: 15584723.
    Abstract:
    The size and positioning of substituents on a tetraene, along with the Woodward-Hoffmann rules, control the relative stereochemistry at the four adjacent chiral centers that are generated in the 8pi/6pi electrocyclization cascade. A biomimetic synthesis of (-)-SNF4435 C and (+)-SNF4435 D exploits these steric effects and allows confirmation of the predicted absolute stereochemistry of the natural products.
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