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  • Title: [Relationship between serum leptin and tumor necrosis factor and endothelin in patients with chronic renal failure].
    Author: Zhang DY, Yang LC, Zhang J, Zhang XL.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2004 Dec; 16(12):750-2. PubMed ID: 15585153.
    Abstract:
    OBJECTIVE: To assess the serum level of leptin and its relationship between tumor necrosis factor, and endothelin in patients with chronic renal failure. METHODS: Serum level of leptin,tumor necrosis factor and endothelin were measured in 40 patients with chronic renal failure and 20 healthy controls by radioimmunoassay. Correlation analysis was performed between serum level of leptin and tumor necrosis factor and endothelin. RESULTS: Serum leptin in patients with chronic renal failure was significantly higher than that in healthy control subjects((19.25+/-4.89)microg/L vs. (5.57+/-1.69)microg/L, P<0.01). There was significant positive correlation between serum leptin and tumor necrosis factor and endothelin (r(TNF)=0.829, r(ET)=0.605; both P<0.01). CONCLUSION: The abnormal increased serum levels of tumor necrosis factor and endothelin are associated with hyperleptinemia in patients with chronic renal failure.
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