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  • Title: Simple surface modification of poly(epsilon-caprolactone) for apatite deposition from simulated body fluid.
    Author: Oyane A, Uchida M, Choong C, Triffitt J, Jones J, Ito A.
    Journal: Biomaterials; 2005 May; 26(15):2407-13. PubMed ID: 15585244.
    Abstract:
    Poly(epsilon-caprolactone) (PCL) with a bone-like apatite layer bound to its surface could be useful as a scaffold for tissue engineering applications. In the present study, the surface of PCL was treated with aqueous NaOH to introduce carboxylate groups onto the surface. The NaOH-treated material was subsequently dipped in aqueous CaCl(2) and K(2)HPO(4).3H(2)O alternately three times to deposit apatite nuclei on the surface. The surface-modified material successfully formed a dense and uniform bone-like surface apatite layer after incubation for 24 h in simulated body fluid with ion concentrations approximately equal to those of human blood plasma.
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