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  • Title: [Diagnosis and therapy of pneumocystosis complicated after renal transplantation].
    Author: Sun M, Yang YR, Lu YP, Wang L, Tang KS, Wei Q, Li H.
    Journal: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 2004 Aug; 22(4):245-7. PubMed ID: 15587162.
    Abstract:
    OBJECTIVE: To investigate the early diagnosis, treatment and prevention of pneumocystosis complicated after renal transplantation. METHODS: Data from 12 cases of kidney transplant recipients who developed pneumocystosis were analyzed by clinical symptoms and signs, results of laboratory examination, imaging, bronchoscopy and biopsy. Combined TMP/SMZ was used for the prevention and treatment. RESULTS: Pneumocystis carinii (Pc) detection rate was 16.7% from alveolar douche, 66.7% with bronchoscopy and biopsy. Two cases was diagnosed by PCR method with sputum. Plain chest film showed 58.3% of lung cirrhosis. CT showed 50% frosted glass-like change in lungs and 25% with lung consolidation. Eleven cases were cured but one died. CONCLUSION: Pc detection by bronchoscopy and biopsy, and PCR are most helpful in the diagnosis of pneumocystosis complicated with renal transplantation, in addition to plain chest film and CT scaning. Combined TMP/SMZ is effective in the prevention and treatment of pneumocystosis.
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