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  • Title: Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates.
    Author: Tomé JP, Neves MG, Tomé AC, Cavaleiro JA, Soncin M, Magaraggia M, Ferro S, Jori G.
    Journal: J Med Chem; 2004 Dec 16; 47(26):6649-52. PubMed ID: 15588101.
    Abstract:
    Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.
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