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  • Title: Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests.
    Author: Piersma AH, Genschow E, Verhoef A, Spanjersberg MQ, Brown NA, Brady M, Burns A, Clemann N, Seiler A, Spielmann H.
    Journal: Altern Lab Anim; 2004 Sep; 32(3):275-307. PubMed ID: 15588168.
    Abstract:
    A detailed report is presented on the performance of the postimplantation rat whole-embryo culture (WEC) test in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded test chemicals, classified as non-embryotoxic, weakly embryotoxic or strongly embryotoxic on the basis of their in vivo effects in animals and/or humans, were tested in four laboratories. The outcome showed that the WEC test can be considered to be a scientifically validated test, which is ready for consideration for use in assessing the embryotoxic potentials of chemicals for regulatory purposes.
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