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  • Title: Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature.
    Author: Crew KD, Cohen MH, Smith DH, Tiersten AD, Feirt NM, Hershman DL.
    Journal: Gynecol Oncol; 2005 Jan; 96(1):235-40. PubMed ID: 15589608.
    Abstract:
    BACKGROUND: Granulosa cell tumors (GCTs) of the ovary are rare, hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse. CASE: We report a case of a prolonged history of ovarian GCT managed primarily with repeat surgical resections. CONCLUSION: This case illustrates the benefits of cytoreductive surgery for the management of recurrent disease, the use of serum tumor markers to help guide therapy, and the importance of extended follow-up.
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